日本人2型糖尿病患者において遺伝子多型は相乗的に作用して頸動脈肥厚を進展させる

Yamasaki Y, Katakami N, Sakamoto K, Kaneto H, Matsuhisa M, Sato H, Hori M, Haneda M, Kashiwagi A, Tanaka Y, Kawamori R, and Kuno S,
Combination of Multiple Genetic Risk Factors Is Synergistically Associated With Carotid Atherosclerosis in Japanese Subjects With Type 2 Diabetes.　Diabetes Care 2006,29: 2445-2451.

日本人2型糖尿病患者における頸動脈壁肥厚度とNAD(P)H 酸化酵素p22 phox遺伝子多型との関連

Hayaishi-Okano R, Yamasaki Y, Kajimoto Y, Sakamoto K, Ohtoshi K, Katakami N, Kawamori D, Miyatsuka T, Hatazaki M, Hazama Y, Hori M,
Association of NAD(P)H Oxidase p22 phox Gene Variation With Advanced Carotid Atherosclerosis in Japanese Type 2 Diabetes. Diabetes Care 2003; 26: 458-63

インスリン抵抗性と血管内皮一酸化窒素合成酵素遺伝子-786T-C多型の関連

Ohtoshi K, Yamasaki Y, Gorogawa S, Hayaishi-Okano R, Node K, Matsuhisa M, Kajimoto Y, Hori M,
Association of (-)786T-C mutation of endothelial nitric oxide synthase gene with insulin resistance. Diabetologia 2002; 45(11): 1594-601

無虹彩症と耐糖能異常に共通する遺伝因子としてのPAX6変異

Yasuda T, Kajimoto Y, Fujitani Y, Watada H, Yamamoto S, Watarai T, Umayahara Y, Matsuhisa M, Gorogawa S, Kuwayama Y, Tano Y,Yamasaki Y, Hori M,
PAX6 mutation as a genetic factor common to aniridia and glucose intolerance. Diabetes 2002; 51: 224-230

2型糖尿病の頸動脈壁肥厚と心筋梗塞危険因子とメチレンテトラハイドロフォレイト
還元酵素遺伝子多型との関連

Arai K, Yamasaki Y, Kajimoto Y, Watada H, Umayahara Y, Kodama M, Sakamoto K, Hori M,
Association of methylenetetrahydrofolate reductase gene polymorphism with carotid arterial wall thickening and myocaridal infarction risk in NIDDM. Diabetes 1997; 46:2102-2104.

心筋梗塞の動脈硬化非依存性危険因子としてのACE遺伝子DD多型

Yamasaki Y, Tsujino T, Kodama M, Kajimoto Y,
DD genotype of the ACE gene as an atherosclerosis-independent risk factor for myocardial infarction. Circulation 1997; 96: 3782 (Letter).

山﨑義光，片上直人：糖尿病・血管合併症のオーダーメイド医療．
バイオ解析・診断技術のテーラーメイド医療への応用：156-164，2006

156-164，2006．

山﨑義光，片上直人：オーダーメイド医療．日本臨床　第64巻・第11号：2148-52，2006．

山﨑義光：糖尿病動脈硬化の成因と治療戦略―オーダーメイド医療を目指して―．プラクティス，23(6)：602-605，2006．（PDF 1,027KB）

インスリン分泌

GCKR(rs780094)/Onuma H/J Hum Genet. 2010 Sep;55(9):600-4. /PMID: 20574426
CDKN2A/B(rs2383208)/Goto A/Diabetes. 2018 May;67(5):872-884./PMID: 29444352
SLC30A8(rs13266634)/Salem SD/BMC Endocr Disord. 2014 Jan 6;14:2. /PMID: 24393180
UBE2E2(rs7612463)/Yamauchi T/Nat Genet. 2010 Oct;42(10):864-8/PMID: 20818381
IGF2BP2(rs1470579)/Horikawa Y/J Clin Endocrinol Metab. 2008 Aug;93(8):3136-41. /PMID: 18477659
CDKAL1(rs2206734)/Goto A/Diabetes. 2018 May;67(5):872-884./PMID: 29444352
KCNQ1(rs2237892)/Yasuda K/Nat Genet. 2008 Sep;40(9):1092-7./PMID: 18711367
TCF7L2(rs7901695)/Horikoshi M,/Diabetologia. 2007 Apr;50(4):747-51./PMID: 17245589
HFE(rs1799945)/Meidtner K/Diabetes Care. 2018 Feb;41(2):277-285./PMID: 29167213

インスリン作用

Adiponectin(rs1501299)/Stumvoll M/Diabetes. 2002 Jan;51(1):37-41./PMID: 11756320
PPARγ(rs1801282)/Deeb SS/Nat Genet. 1998 Nov;20(3):284-7./PMID: 9806549
PGC-1(rs8192678)/Muller YL/Diabetes. 2003 Mar;52(3):895-8./PMID: 12606537
EPHX2(rs751141)/Ramirez CE/Prostaglandins Other Lipid Mediat. 2014 Oct;113-115 /PMID: 25173047
RTEN(rs1862513)/Onuma H/PLoS One. 2010 Mar 16;5(3):e9718./PMID: 20300528
MCP-1(rs1024611)/Simeoni E/Diabetologia. 2004 Sep;47(9):1574-80. /PMID: 15349727
IRS-1(rs1801278)/Zhang Y/Sci Rep. 2014 Aug 22;4:6113./PMID: 25146448
グリコーゲン合成酵素(rs5447)/Shimomura H/Diabetologia. 1997 Aug;40(8):947-52./PMID: 9267990

糖尿病腎症

PON1(rs662)/Ichikawa K/Kidney Int. 2009 Jul;76(2):183-9/PMID: 19357718
MTHFR(rs1801133)/Hishida A/Int Urol Nephrol. 2013 Dec;45(6):1613-20./PMID: 23595572
MS(rs1805087)/Hishida A/Int Urol Nephrol. 2013 Dec;45(6):1613-20./PMID: 23595572
NOS3(rs2070744)/Dellamea BS/Diabetol Metab Syndr. 2014 Feb 12;6(1):17./PMID: 24520999
PAI-1(rs1799768)/Xu F/Ren Fail. 2016;38(1):157-62. /PMID: 26616527
Mn-SOD(rs4880)/Abbasi M/Nutr Metab (Lond). 2018 Apr 11;15:25./PMID: 29681991
CCR5(rs1799987)/Yadav AK/J Diabetes. 2014 Nov;6(6):547-55. /PMID: 24433479
PIGR1(rs291102)/Obara W/J Hum Genet. 2003;48(6):293-9./PMID: 12740691

糖尿病網膜症

VEGF(rs2010963)/Lu Y,/BMC Ophthalmol. 2013 Oct 16;13:56./PMID: 24131746
ALR(rs759853)/Zhou M/Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2279-89./PMID: 25722213
GLUT(rs841853)/Tarnow L/Nephrol Dial Transplant. 2001 Aug;16(8):1653-6./PMID: 11477169
PAI-1(rs1799768)/Xu F/Ren Fail. 2016;38(1):157-62. /PMID: 26616527
MCP-1(rs1024611)/Katakami N/Diabetes Res Clin Pract. 2010 Jul;89(1):e9-12./PMID: 20488574
PON1(rs662)/Ichikawa K/Kidney Int. 2009 Jul;76(2):183-9/PMID: 19357718
UCP2(rs659366)/Shen Y/PLoS One. 2014 Nov 14;9(11):e112670. /PMID: 25396419

骨祖しょう症

ESR1(rs2234693)/Wang C/J Bone Miner Res. 2012 Dec;27(12):2582-91/PMID: 22807154
VDR(rs1544410)/Jia F/Genet Test Mol Biomarkers. 2013 Jan;17(1):30-4/PMID: 23134477
IL-6(rs1800796)/Oishi Y/Gene. 2012 Aug 1;504(1):75-83./PMID: 22579472
ALDH7A1(rs13182402)/Guo Y/PLoS Genet. 2010 Jan 8;6(1):e1000806./PMID: 20072603

ロコモ

ACTN3(rs1815739)/Kikuchi N/Eur J Sport Sci. 2016 Sep;16(6):694-701. /PMID: 26324221
ACE(rs4337)/Gunel T/Mol Med Rep. 2014 Apr;9(4):1422-6./PMID: 24566537
BDKRB2(rs1799722)/Tsianos GI/J Appl Physiol (1985). 2010;108(3):567–574./PMID: 20044476
VDR2(rs1544410)/Wang P/Int J Sports Med. 2006 Mar;27(3):182-6./PMID: 16541372
TNFα(rs1800629)/Di Renzo L/Dis Markers. 2013;35(6):615-23./PMID: 24285913

非アルコール性脂肪性肝疾患

PNPLA3(rs738409)/Romeo S/Nat Genet. 2008 Dec;40(12):1461-5/PMID: 18820647
NOS2(rs1060822)/Yoneda M/Hepatol Res. 2009 Oct;39(10):963-71./PMID: 19624767
PPARGC1A1(rs2290602)/Yoneda M/BMC Gastroenterol. 2008 Jun 27;8:27/PMID: 18588668
TNFA2(rs361525)/Valenti L/Gastroenterology. 2002 Feb;122(2):274-80/PMID: 11832442
RETN2(rs3745367)/Zhang LY/Gene. 2013 Oct 25;529(2):340-4/PMID: 23954219
MTP(rs1800591)/Fujita K/J Pharmacol Sci. 2011;115(3):270-3./PMID: 21350309
Mn-SOD(rs4880)/Namikawa C,/J Hepatol. 2004 May;40(5):781-6./PMID: 15094225

もの忘れ

APOE(rs429358, rs7412) Yoshizawa T/Ann Neurol 1994 Oct; 36(4):656-659./PMID 7944299

動脈硬化

LTA(rs909253)/Clarke R/PLoS Genet. 2006 Jul;2(7):e107./PMID: 16839190
MTHFR(rs1801133)/Kluijtmans LA/1997 Dec;46(12):2102-4./PMID: 9392503
MS(rs1805087) /Li WX/Lipids Health Dis. 2015 Sep 4;14:101. /PMID: 26337056
Adiponectin(rs1501299) /Bacci S/Diabetes Care. 2004 Aug;27(8):2015-20./PMID: 15277433
ACE(rs4340) /Yamasaki Y/Diabetes Care. 2006 Nov;29(11):2445-51./PMID: 17065682
VEGF(rs2010963) /Howell WM/J Med Genet. 2005 Jun;42(6):485-90./PMID: 15937083
Cx37(rs1764391)/Yamada Y/N Engl J Med. 2002 Dec 12;347(24):1916-23./PMID: 12477941
F12(rs1801020) /Santamaría A/Haematologica. 2004 Jul;89(7):878-9./PMID: 15257949

心筋梗塞

LTA(rs909253)/Ozaki/Nat Genet. 2002 Dec;32(4):650-4./PMID: 12426569
GCLM(rs41303970)/Nakamura S,/Circulation. 2002 Jun 25;105(25):2968-73./PMID: 12081989
NOS3(rs2070744)/Kong XZ/Med Sci Monit. 2017 Feb 11;23:759-766./PMID: 28188309
PON1(rs662)/Dahabreh IJ/Genet Med. 2010 Oct;12(10):606-15. /PMID: 20856122
E-selectin(rs1805193)/Zheng F/Clin Genet. 2001 Jan;59(1):58-64./PMID:11168027
LRP(rs715948)/Benes P/J Mol Med (Berl). 2001 Apr;79(2-3):116-20./PMID: 11357934
ENPP1(rs1044498)/Bacci S/Diabetes. 2005 Oct;54(10):3021-5./PMID: 16186408
βFib(rs1800787)/Behague I/Circulation. 1996 Feb 1;93(3):440-9./PMID: 8565160

脳梗塞

LTA(rs909253)/Zhao N,/J Neuroinflammation. 2012 Jul 6;9:162./PMID: 22769019
SELP(rs6131)/Zhao N/J Neuroinflammation. 2012 Jul 6;9:162./PMID: 22769019
IL-18(rs1946518)/Mitrokhin V/J Inflamm Res. 2018 Jan 18;11:1-9. /PMID: 29403300
PON1(rs662)/Dahabreh IJ/Genet Med. 2010 Oct;12(10):606-15. /PMID: 20856122
angiotensinogen(rs699)/Park HK,/Exp Ther Med. 2013 Jan;5(1):343-349. /PMID: 23251296
ICAM1(rs5498)/Palmer CN/Diabetes. 2010 Nov;59(11):2945-8./PMID: 20622166
ACE(rs1799752)/Sharma P./J Neurol Neurosurg Psychiatry. 1998 Feb;64(2):227-30./PMID: 9489536
Cx37(rs1764391)/Leu HB/Atherosclerosis. 2011 Jan;214(1):101-6./PMID: 21044781
E-selectin(rs1805193)/Zheng F/Clin Genet. 2001 Jan;59(1):58-64./PMID:11168027
TNF-α(rs1800629)/Cui G/J Neuroinflammation. 2012 Oct 10;9:235/PMID: 23050663
GPIa(rs1126643)/Wu G/nt J Neurosci. 2014 Nov;124(11):841-51./PMID: 24397542
PAI-1(rs1799768)/Cao Y/Int J Neurosci. 2014 Dec;124(12):874-81./PMID: 24472072